Dana-Farber Center for BRCA & Related Genes Annual Scientific Symposium

Registration and Breakfast, Yawkey 306-307 

Opening Remarks
Panagiotis Konstantinopoulos, MD, PhD 

Bytes to Beside: Mutational Signatures in BRCA1/BRCA2-Deficiency and Clinical Updates
Serena Nik-Zainal, PhD 

How is Prevention in the Genes?
Fatima Karzai, MD 

Homologous Recombination Licensing Role of BRCA1
Patrick Sung, DPhil

Lunch Break, Yawkey 306-307 

Therapeutic Exploration of Homologous Recombination Deficient in Pancreatic Cancer
Talia Golan, MD 

Homologous Recombination Deficiency in Prostate Cancer: Implications for Early Detection and Management of Localized Disease
Keyan Salari, MD, PhD 

Developing Medicines to Exploit Novel and Mature DDR Targets
Ian Smith, MD 

Resistance to HRD Targeting Agents
Chris Lord, PhD 

Afternoon Break, Yawkey 306-307 

Leveraging Epigenetics to Address Unmet Needs in BRCAness Ovarian Cancer
Rugang Zhang, PhD 

PARPi/ADC Combinations
Elizabeth K. Lee, MD  

Overcoming PARPi Resistance by Understanding BRCA1-Dependent and BRCA1-Independent HR 
Yizhou He, PhD 

Closing Remarks
Panagiotis Konstantinopoulos, MD, PhD