Dana-Farber Center for BRCA & Related Genes Annual Scientific Symposium

Registration and Breakfast, Yawkey 306-307 

Opening Remarks
Panagiotis Konstantinopoulos, MD, PhD 

Bytes to Beside: Mutational Signatures in BRCA1/BRCA2-Deficiency and Clinical Updates
Serena Nik-Zainal, PhD 

How is Prevention in the Genes?
Fatima Karzai, MD 

Homologous Recombination Licensing Role of BRCA1
Patrick Sung, DPhil

Therapeutic Exploration of Homologous Recombination Deficient in Pancreatic Cancer
Talia Golan, MD

Lunch Break, Yawkey 306-307

Homologous Recombination Deficiency in Prostate Cancer: Implications for Early Detection and Management of Localized Disease
Keyan Salari, MD, PhD 

Discovery and Preclinical Evaluation of DNA Polymerase Theta Inhibitors for Potentiating PARP Inhibitor Efficacy
Graeme Smith, MD 

Resistance to HRD Targeting Agents
Chris Lord, PhD 

Afternoon Break, Yawkey 306-307 

Leveraging Epigenetics to Address Unmet Needs in BRCAness Ovarian Cancer
Rugang Zhang, PhD 

A Phase 1 trial of DS8201a and Olaparib in HER2-expressing Solid Tumors
Elizabeth K. Lee, MD  

Overcoming PARPi Resistance by Understanding BRCA1-Dependent and BRCA1-Independent HR 
Yizhou He, PhD 

Closing Remarks
Panagiotis Konstantinopoulos, MD, PhD